0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Loss and Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Loss and Comprehensive Loss (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Changes in Stockholders’ Equity link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Nature of Operations link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Recent Accounting Pronouncements link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Net Loss per Share link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Cash, Cash Equivalents and Marketable Securities link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - IPR&D and Goodwill link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Property and Equipment link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Intangible Assets link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Liabilities link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Research, Collaboration and Licensing Agreements link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Other Income (Expense), net link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Commitment and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Business Segments link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Subsequent event link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Net Loss per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Cash, Cash Equivalents and Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - IPR&D and Goodwill (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Property and Equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Intangible Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Research, Collaboration and Licensing Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Other Income (Expense), net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Commitment and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Business Segments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Summary of Significant Accounting Policies - Concentration of Credit Risk (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Summary of Significant Accounting Policies - Summary of Estimated Useful Lives (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Summary of Significant Accounting Policies - Summary of Definite-lived Intangible Assets, Estimated Useful Lives (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Net Loss per Share - Schedule of Calculation of Diluted Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Cash, Cash Equivalents and Marketable Securities - Schedule of Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Cash, Cash Equivalents and Marketable Securities - Schedule of Assets Measured at Fair Value on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - IPR&D and Goodwill - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - IPR&D and Goodwill - Summary of Carrying Value of IPR&D, Net of Impairment (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Property and Equipment - Components of Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Property and Equipment - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Intangible Assets - Schedule of Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Intangible Assets - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Intangible Assets - Schedule of Future Amortization Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Liabilities - Schedule of Accounts Payable and Accrued Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Liabilities - Schedule of Other Long-Term Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Stockholders' Equity - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Stockholders' Equity - Repurchase Program Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Stockholders' Equity - Schedule of RSUs Outstanding (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Stockholders' Equity - Summary of Stock Options Granted (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Stockholders' Equity - Schedule of Non-Vested Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Stockholders' Equity - Schedule of Stock-based Compensation Expense for Equity Classified Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Stockholders' Equity - Schedule of Estimated Fair Value of Stock Options Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Research, Collaboration and Licensing Agreements - Schedule Of Collaborative Arrangements and Noncollaborative Arrangement Transactions (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Research, Collaboration and Licensing Agreements - Contract Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Research, Collaboration and Licensing Agreements - Jazz Collaboration Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Research, Collaboration and Licensing Agreements - Collaboration and License Agreements with BeiGene, Ltd. (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Research, Collaboration and Licensing Agreements - 2020 Research and License Agreement with Merck (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Research, Collaboration and Licensing Agreements - Celgene Corporation and Celgene Alpine Investment Co. LLC (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Research, Collaboration and Licensing Agreements - GlaxoSmithKline Intellectual Property Development Ltd. (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Research, Collaboration and Licensing Agreements - 2016 Platform Technology Transfer and License Agreement with GSK (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Research, Collaboration and Licensing Agreements - 2016 Collaboration Agreement with Daiichi Sankyo, Co., Ltd. (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Research, Collaboration and Licensing Agreements - 2018 Licensing Agreement with Daiichi Sankyo (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Research, Collaboration and Licensing Agreements - Collaboration and License Agreement with Janssen Biotech, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Research, Collaboration and Licensing Agreements - Research and License Agreement with LEO Pharma A/S (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Other Income (Expense), net -Schedule Of Other Non operating Income Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Income Taxes - Schedule of Loss Before Provision for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Income Taxes - Schedule of Income Tax Expense (Recovery) (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Income Taxes - Schedule of Significant Components of Deferred Income Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Income Taxes - Schedule of Significant Components of Deferred Income Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955566 - Disclosure - Income Taxes - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955567 - Disclosure - Income Taxes - Schedule of Reconciliation of Beginning and Ending Amounts of Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 9955568 - Disclosure - Income Taxes - Schedule of Cash Income Taxes Paid (Details) link:presentationLink link:calculationLink link:definitionLink 9955569 - Disclosure - Leases - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955570 - Disclosure - Leases - Schedule of Balance Sheet Classification of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955571 - Disclosure - Leases - Schedule of Future Minimum Lease Payment Operating Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955571 - Disclosure - Leases - Schedule of Future Minimum Lease Payment Operating Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955572 - Disclosure - Leases - Schedule of Cost Components of Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955573 - Disclosure - Commitment and Contingencies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955574 - Disclosure - Commitment and Contingencies - Summary of Changes in Fair Value of the Company's Liability for Contingent Consideration (Details) link:presentationLink link:calculationLink link:definitionLink 9955575 - Disclosure - Business Segments - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955576 - Disclosure - Business Segments - Schedule of Segment Reporting Information, by Segment (Details) link:presentationLink link:calculationLink link:definitionLink 9955577 - Disclosure - Subsequent event (Details) link:presentationLink link:calculationLink link:definitionLink